Trauma Immunopathology Research Laboratory
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Publications
- Sasaki, JR, Zhang, Q, Schwacha, MG. (2011) Burn induces a Th-17 inflammatory response
at the injury site. Burns 37: 469-651.
- Oppeltz, R.F., Zhang, Q., Rani, M., Sasaki, J.R., Schwacha MG (2010)
Increased expression of cardiac IL-17 after burn. Journal of Inflammation 7:38
- Chung, K.K., Wolf, S.E., Renz, E.M., Allan, P.F., Aden, J.K., Merrill, G.A.,
Shelhamer, M.C., King, B.T., White, C.E., Bell, D.G., Schwacha MG, Wanek,
S.M., Wade, C.E., Holcomb, J.B., Blackbourne, L.H., Cancio, L.C. (2010) High
frequency percussive ventilation and low tidal volume ventilation in burns: a
randomized controlled trial. Critical Care Medicine (Epub ahead of print).
- Schwacha MG, Thobe, B.M., Daniel, T, Hubbard, W.J. (2010) Impact of
thermal injury on wound infiltration and the dermal inflammatory response.
Journal of Surgical Research 158:112-120.
- Hsieh, C-H, Nickel, E.A., Hsu, J-T, Schwacha MG, Bland, K.I., Chaudry,
I.H. (2009) Trauma-hemorrhage and hypoxia differentially influence Kupffer cell
phagocytic capacity: Role of hypoxia-inducible-factor-1αand phosphoinositide
3-kinase/Akt activation. Annals of Surgery 250:995-1001.
- Nickel, E.A., Hsieh, C-H, Chen, J.G., Schwacha MG, Chaudry, I.H. (2009)
Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via a hypoxia inducible
factor-1α-mediated pathway Shock 31:354-358.
- Hsieh, C.H., Nickel, E.A., Chen, J., Schwacha MG, Choudhry, M.A., Bland,
K.I., Chaudry, I.H. (2009) Mechanism of the salutary effects of estrogen on
Kupffer cell phagocytic capacity following trauma-hemorrhage. Journal of
Immunology 182:4406-4414.
- Kawasaki, T., Choudhry, M.A., Schwacha MG, Bland, K.I., Chaudry, I.H.
(2009) Effect of interleukin-15 on depressed splenic dendritic cell functions
following trauma-hemorrhage. American Journal of Physiology-Cell Physiology
296:C124-C130.
- Schwacha MG (2009) γδ T-Cells: Potential regulators of the post-burn
inflammatory response. Burns 35:318-326.
- Schwacha MG, Daniel, T. (2008) Up-regulation of cell surface toll-like
receptors on circulating γδ T-cells following burn injury. Cytokine 44:328-334.
- Hsieh CH, Nickel EA, Chen J, Schwacha MG, Choudhry MA, Bland KI, Chaudry IH.
(2009)
Mechanism of the salutary effects of estrogen on Kupffer cell phagocytic capacity following trauma-hemorrhage.
Journal of Immunology 182:4406-4414.
- Kawasaki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH.
(2009)
Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage.
American Journal of Physiology-Cell Physiology 296:C124-C130.
- Schwacha MG.
(2009)
βδ T-Cells: Potential regulators of the post-burn inflammatory response.
Burns 35:318-326.
- Schwacha MG, Daniel, T.
(2008)
Up-regulation of cell surface toll-like receptors on circulating βδ T-cells following burn injury.
Cytokine 44:328-334.
- Schwacha M.G. (2008) Opiates and the development of post-injury
complications: a review. International Journal of Clinical and
Experimental Medicine 1:42-49.
- Kawasaki, T., Choudhry, M.A., Schwacha, M.G., Fujimi, S., Lederer,
J.A., Bland, K.I., Chaudry, I.H. (2008) Trauma-hemorrhage inhibits
splenic dendritic cell proinflammatory cytokine production via a
mitogen-activated protein kinase process. American Journal of
Physiology-Cellular Physiology 294:C754-C764.
- Hsieh, C-H, Frink, M., Hsieh, Y-C, Kan, W-H, Hsu, J-T, Schwacha,
M.G., Choudhry, M.A., Chaudry, I.H. (2008) The role of MIP-1α in the
development of systemic inflammatory response and organ injury following
trauma-hemorrhage. Journal of Immunology 181:2806-2812.
- Hsu J.T., Kan W.H., Hsieh Y.C., Choudhry M.A., Schwacha MG., Bland
K.I., Chaudry I.H. (2008) Mechanism of estrogen mediated improvement in
cardiac function following trauma-hemorrhage: p38-depencent
normalization of cardiac AKt phosphorylation and glycogen levels. Shock
30:372-378.
- Li X., Schwacha, M.G., Chaudry, I.H., Choudhry, M.A. (2008)
Inhibition of protein tyrosine phosphatases prevents mesenteric lymph
node T cell suppression following alcohol intoxication and burn injury.
Journal of Burn Care and Research 29:519-530.
- Ba, Z.F., Hsu, J-T, Chen, J., Kan, W-H, Schwacha, M.G., Chaudry,
I.H. (2008) Systematic analysis of the salutary effect of estrogen on
cardiac performance following trauma-hemorrhage. Shock 30:585-589.
- Kan, W-H, Hsu, J-T, Ba Z-F, Schwacha, M.G., Chen J-G, Choudhry,
M.A., Bland, K.I., Chaudry, I.H. (2008) p38 MAPK dependent eNOS
upregulation is critical for 17β-estradiol-mediated cardioprotection
following trauma-hemorrhage. American Journal of Physiology-Heart and
Circulatory Physiology 294:H2627-2636.
- Hsu, J-T, Kan, W-H, Hsieh Y-C, Choudhry, M.A. Schwacha, M.G., Bland,
K.I., Chaudry, I.H. (2008) Mechanism of estrogen-mediated intestinal
protection following trauma-hemorrhage: p38-dependent upregulation of
HO-1. American Journal of Physiology-Regulatory, Integrative and
Comparative Physiology 294:H2627-2636.
- Kan, W-H, Hsieh, C-H, Schwacha, M.G., Choudhry, M.A., Raju, R.,
Bland, K.I., Chaudry, I.H. (2008) Flutamide protects against
trauma-hemorrhage-induced liver injury via attenuation of the
inflammatory response, oxidative stress and apoptosis. Journal of
Applied Physiology 105:595-602.
- Schwacha, M.G., Nickel, E., Daniel, T. (2008) Burn injury-induced
alterations in wound inflammation and healing are associated with
suppressed hypoxia inducible factor-1? expression. Molecular Medicine
14:628-633.
- Hsu, J-T, Kan, W-H, Hsieh Y-C, Choudhry, M.A. Schwacha, M.G., Bland,
K.I., Chaudry, I.H. (2008) Mechanism of estrogen-mediated improvement in
cardiac function after trauma-hemorrhage: p38-dependent normalization of
cardiac Akt phosphorylation and glycogen levels. Shock 30:372-378.
- Kan, W-H, Hsu, J-T, Schwacha, M.G., Choudhry, M.A., Raju, R., Bland,
K.I., Chaudry, I.H. Selective inhibition of iNOS attenuates
trauma-hemorrhage/resuscitation-induced hepatic injury. Journal of
Applied Physiology 105:1076-1082.
- Kan,W-H, Hsu,J-T, Schwacha, M.G., Choudhry, M.A., Raju, R., Bland,
K.I., Chaudry, I.H. (2008) Estrogen ameliorates
trauma-hemorrhage-induced lung injury via endothelial nitric oxide
synthase-dependent activation of protein kinase G. Annals of Surgery
248:294-302.
- Li, X., Schwacha, M.G., Chaudry, I.H., Choudhry, M.A. (2008) Heme
oxygenase-1 protects against neutrophil-mediatd intestinal damage by
down-regulation of neutrophil p47phox and p67phox activity and O2-
production in a two-hit model of alcohol intoxication and burn injury.
Journal of Immunology 180:6933-6940.
- Suzuki, T., Shimizu, T., Yu, H-P, Hsieh, Y-C, Choudhry, M.A.,
Schwacha, M.G., Chaudry, I.H. (2007) Tissue-compartment-specific role of
estrogen receptor subtypes in immune cell cytokine production following
trauma-hemorrhage. Journal of Applied Physiology 102:163-168.
- Schneider, C.P., Schwacha, M.G., Chaudry, I.H. (2007) Impact of
gender and age on bone marrow immune responses in a murine model of
trauma-hemorrhage. Journal of Applied Physiology 102:113-121.
- Ba, Z.F., Lu, A., Shimizu, T., Szalay, L., Schwacha, M.G., Rue,
L.W., III, Bland, K.I., Chaudry, I.H. (2006) 17β-estradiol modulates
vasoconstriction induced by endothelin-1 following trauma-hemorrhage.
American Journal of Physiology-Heart and Circulatory Physiology
291:H245-H250.
- Hsieh, Y-C, Frink, M., Thobe, B.M., Hsu, J-T, Choudhry, M.A.,
Schwacha, M.G., Bland, K.I., Chaudry, I.H. (2007) 17β-estradiol
downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and
normalizes inflammatory cytokine production following trauma-hemorrhage.
Molecular Immunology 44:2165-2172.
- Frink, M., Hsieh, Y-C, Thobe, B.M., Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) TLR4 regulates Kupffer cell chemokine
production, systemic inflammation and lung neutrophil infiltration
following trauma-hemorrhage. Molecular Immunology 44:2625-2630
- Frink, M., Lu, A., Thobe, B.M., Hsieh, Y-C, Choudhry, M.A.,
Schwacha, M.G., Kunkel, S.L., Chaudry, I.H. (2007) Monocyte
chemoattractant protein-1 influences trauma-hemorrhage-induced distal
organ damage via regulation of keratinocyte-derived chemokine
production. American Journal of Physiology-Integrative and Comparative
Physiology 292:R1110-R1116.
- Lu, A., Frink M., Choudhry M.A., Schwacha, M.G., Hubbard W.J., Rue
III, L.W., Bland, K.I., Chaudry I.H. (2007) Mitochondria play an
important role in 17β-estradiol attenuation of H2O2-induced endothelial
cell apoptosis. American Journal of Physiology-Endocrinology and
Metabolism 292:E585-E593.
- Frink, M., Thobe, B.M., Hsieh, Y-C, Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) 17β-estradiol inhibits
keratinocyte-derived chemokine production following trauma-hemorrhage.
American Journal of Physiology-Lung Cell and Molecular Physiology
292:L585-L591.
- Hsieh Y.C., Frink M., Thobe B.M., Kawasaki T., Choudhry M.A.,
Schwacha M.G., Bland K.I., Chaudry I.H. (2007) Downregulation of
TLR4-dependent ATP production is critical for estrogen-mediated
immunoprotection in Kupffer cells following trauma-hemorrhage. Journal
of Cellular Physiology 211:364-370.
- Hsieh, Y-C, Yu, H-P, Frink, M., Suzuki, T., Choudhry, M.A.,
Schwacha, M.G., Chaudry, I.H. (2007) G protein-coupled receptor
30-dependent protein kinase A pathway is critical in non-genomic effects
of estrogen in attenuating liver injury after trauma. American Journal
of Pathology 170:1210-1218.
- Moeinpour, F., Choudhry, M.A., Kawasaki, T., Timares, L., Schwacha,
M.G., Bland, K.I., Chaudry, I.H. (2007) 17β-estradiol normalizes Toll
receptor 4, mitogen activated protein kinases and inflammatory response
in epidermal keratinocytes following trauma-hemorrhage. Molecular
Immunology 44:3317-3323.
- Yu, H-P, Hsieh, Y-C, Suzuki, T., Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) The PI3K/Akt pathway mediates the
non-genomic cardioprotective effects of estrogen following
trauma-hemorrhage. Annals of Surgery 245:971-977.
- Daniel, T., Thobe, B.M., Chaudry, I.H. Choudhry, M.A., Hubbard,
W.J., Schwacha, M.G. (2007) Regulation of the post-burn wound
inflammatory response by ?? T-cells Shock 28:278-283.
- Yu, H-P, Hsieh, Y-C, Suzuki, T., Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) Mechanism of the non-genomic effects
of estrogen on intestinal myeloperoxidase activity following
trauma-hemorrhage: Upregulation of PI3K/Akt. Journal of Leukocyte
Biology 82:774-780.
- Li X., Kovacs E.J., Schwacha, M.G., Chaudry I.H., Choudhry M.A.
(2007). Acute alcohol intoxication increases interleukin 18-mediated
neutrophil infiltration and lung inflammation following burn injury in
rats. American Journal of Physiology-Lung Cellular and Molecular
Physiology 292:L1193-L1201.
- Frink, M., Hsieh Y-C, Hu, S., Hsieh, C.H., Pape, H.C., Choudhry,
M.A., Schwacha, M.G., Bland, K.I., Chaudry, I.H. (2007) Mechanism of
salutary effects of Finasteride on post-traumatic immune/inflammatory
response: Upregulation of estradiol synthesis. Annals of Surgery
246:836-843.
- Hsieh, Y-C, Frink, M., Hsieh, C-H, Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) Downregulation of migration inhibitory
factor is critical for estrogen-mediated attenuation of lung tissue
damage following trauma-hemorrhage. American Journal of Physiology-Lung
Cellular and Molecular Physiology 292:L1227-L1232.
- Hsu, J-T, Hsieh, Y-C, Kan, W-H, Chen, J-G, Choudhry, M.A., Schwacha,
M.G., Bland, K.I., Chaudry, I.H. (2007) Role of p38 mitogen-activated
protein kinase pathway in estrogen-mediated cardioprotection following
trauma-hemorrhage. American Journal of Physiology-Heart and Circulatory
Physiology 292:H2982-H2987.
- Hsu, J-T, Kan, W-H, Hsieh, C-H, Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) Mechanism of estrogen-mediated
attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent
HO-1 up-regulation. Journal of Leukocyte Biology 82:1019-1026.
- Yu, H-P, Hsieh, Y-C, Suzuki, T., Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2007) Mechanism of the nongenomic effects of
estrogen on intestinal myeloperoxidase activity following
trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway. Journal of
Leukocyte Biology 82:774-780.
- Alexander, M., Daniel, T., Chaudry, I.H., Choudhry, M.A., Schwacha,
M.G. (2006) T-cells of the γδ T cell receptor lineage play an important
role in the post-burn wound healing process. Journal of Burn Care and
Research. 1:18-25. (Robert A Lindberg Award Recipient)
- Hsieh, Y.C., Yang, S., Choudhry, M.A., Yu, H.P., Bland, K.I.,
Schwacha, M.G., Chaudry, I.H. (2006) Flutamide restores cardiac
functions following trauma-hemorrhage via an estrogen-dependent pathway
through upregulation of PGC-1. American Journal of Physiology-Heart and
Circulatory Physiology 290:H416-H423
- Yu, H-P, Choudhry, M.A., Shimizu, T., Hsieh, Y-C., Schwacha, M.G.,
Yang, S., Chaudry, I.H. (2006) Mechanism of the salutary effects of
flutamide on intestinal myeloperoxidase activity following
trauma-hemorrhage: Upregulation of estrogen receptor-β-dependent HO-1.
Journal of Leukocyte Biology 79:277-284.
- Szalay, L., Shimizu, T., Suzuki, T., Yu, H-P, Choudhry, M.A.,
Schwacha, M.G., Rue, L.W. III, Bland, K.I., Chaudry, I.H. (2006)
Estradiol improves cardiac and hepatic function following
trauma-hemorrhage: role of enhanced heat shock protein expression.
American Journal of Physiology-Regulatory, Integrative and Comparative
Physiology 290:R812-R818.
- Schneider, C.P., Schwacha, M.G., Chaudry, I.H. (2006) The influence
of gender and age on T-cell responses in a murine model of
trauma-hemorrhage: Differences between circulating and tissue fixed
cells. Journal of Applied Physiology 100:826-833.
- Brownstein, B.H., Logvinenko, T., Lederer, J.A., Cobb, J.P.,
Hubbard, W.J., Chaudry, I.H., Remick, D.G., Baker, H.V., Xiao, W.,
Mannick, J.A., Inflammation and Host Response to Injury Large Scale
Collab. Res. Program (including Schwacha M.). (2006) Commonality and
differences in leukocyte gene expression patterns among three models of
inflammation and injury. Physiol Genomics 24:298-309.
- Laudanski, K., Miller-Grazino, C., Xiao W., Mindrinos, M.N.,
Richards, D.R., De, A., Moldawer, L.L., Maier, R.V., Bankey, P., Baker,
H.V., Brownstein, B.B., Cobb, J.P., Calvano, S.E., Davis, R.W.,
Tompkins, R.G. Inflammation and Host Response to Injury Large Scale
Collab. Res. Program (including Schwacha M.). (2006) Cell specific
expression and pathway analyses reveal alterations in trauma-related
human T cell and monocyte pathways. Proceedings of the National Academy
of Sciences 103:15564-15569.
- Liu, T., Qian, W-J, Gritsenko, M.A., Xiao, W., Moldawer, L.L.,
Kaushal, A., Monroe, M.E., Varnun, S.M., Moore, R.J., Purvine, S.O.,
Maier, R.V., Davis, R.W., Tompkins, R.G., Inflammation and Host Response
to Injury Large Scale Collab. Res. Program (including Schwacha M.).
(2006) High dynamics range characterization of trauma patient plasma
proteome. Molecular and Cellular Proteomics. 5:1899-1913.
- Li, X., Schwacha, M.G., Chaudry, I.H., Choudhry, M.A. (2006) A role
of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit
rodent model of alcohol intoxication and injury. Journal of Leukocyte
Biology 79:963-970.
- Yu, H-P, Hsieh, Y-C, Suzuki, T., Shimizu, T., Choudhry, M.A.,
Schwacha, M.G., Chaudry, I.H. (2006) Salutary effects of estrogen
receptor-β agonist on lung injury following trauma-hemorrhage American
Journal of Physiology-Lung Cellular and Molecular Physiology
290:L1004-L1009.
- Yu, H-P, Shimizu, T., Hsieh, Y-C, Suzuki, T., Choudhry, M.A.,
Schwacha, M.G., Chaudry, I.H. (2006). Tissue-specific expression of
estrogen receptors and their role in the regulation of neutrophil
infiltration in various organs following trauma-hemorrhage. Journal of
Leukocyte Biology 79:963-970.
- Daniel, T., Alexander, M., Hubbard, W.J., Chaudry, I.H., Choudhry,
M.A., Schwacha, M.G. (2006) Nitric oxide contributes to the development
of post-injury immune dysfunction and a Th-2 T-Cell phenotype. Journal
of Cellular Physiology 208:418-427.
- Schwacha, M.G., McGwin, G., Jr., Hutchinson, C.B., Cross, J.M.,
MacLennan, P.A., Rue, L.W., III. (2006) The contribution of opiate
analgesics to the development of infectious complications in burn
patients. American Journal of Surgery 192:82-86.
- Hsieh, Y-C, Yu, H-P, Suzuki, T., Choudhry, M.A., Schwacha, M.G.,
Bland, K.I., Chaudry, I.H. (2006) Upregulation of mitochondrial
respiratory complex IV by estrogen receptor-β is critical for inhibiting
mitochondrial apoptotic signaling and restoring cardiac functions
following trauma-hemorrhage. Journal of Molecular and Cellular
Cardiology 41:511-521.
- Kawasaki, T., Hubbard, W.J., Choudhry, M.A., Schwacha, M.G., Bland,
K.I., Chaudry, I.H. (2006) Trauma-hemorrhage induces depressed splenic
dendritic cell functions in mice. Journal of Immunology 177:4514-4520.
- Li X., Rana S.N., Schwacha M.G., Chaudry I.H., Choudhry, M.A. (2006)
A novel role for IL-18 in corticosterone-mediated intestinal damage in a
two-hit rodent model of alcohol intoxication and injury. Journal of
Leukocyte Biology 80:367-75.
- Thobe, B.M., Frink, M., Choudhry, M.A., Schwacha, M.G., Bland, K.I.,
Chaudry, I.H. (2006) Src family kinases regulate p38 MAPK-mediated IL-6
production in Kupffer cells following hypoxia. American Journal of
Physiology-Cell Physiology 291:C476-C482.
- Szalay, L., Shimizu, T., Suzuki, T., Hsieh, Y-C, Choudhry, M.A.,
Schwacha, M.G., Bland, K.I., Chaudry, I.H. (2006) Androstenediol
administration after trauma-hemorrhage attenuates inflammatory response,
reduces organ damage and improves survival following sepsis. American
Journal of Physiology-Gastrointestinal and Liver Physiology
291:G260-G266.
- Kawasaki, T., Choudhry, M.A., Schwacha, M.G., Bland, K.I., Chaudry,
I.H. (2006) Lidocaine depresses splenocyte immune functions following
trauma-hemorrhage in mice. American Journal of Physiology-Cell
Physiology 291:C1049-C1055.
- Thobe, B.M., Hildebrand, F., Frink, M., Schwacha, M.G., Hubbard,
W.J., Choudhry, M.A., Chaudry, I.H. (2006) The role of MAPK in Kupffer
cell Toll like receptor (TLR) 2-, 4-, and 9-mediated signaling following
trauma-hemorrhage. Journal of Cellular Physiology 210:667-675.
- Shimizu, T., Szalay, L., Choudhry, M.A., Schwacha, M.G., Rue, L.W.,
III, Bland, K.I., Chaudry, I.H. (2005) Mechanism of salutary effects of
androstenediol on hepatic function following trauma-hemorrhage: the role
of endothelial and inducible nitric oxide synthase. American Journal of
Physiology-GI and Liver Physiology 288: G244-G250.
- Schwacha, M.G., Holland, L.T., Chaudry, I.H., Messina, J.L. (2005)
Genetic variability in the immune-inflammatory response after major burn
injury. Shock 23: 123-128.
- Szalay, L., Shimizu, T., Schwacha, M.G., Choudhry, M.A., Rue, L.W.,
III, Bland, K.I., Chaudry, I.H. (2005) Mechanism of the salutary effects
of estradiol on organ function following trauma-hemorrhage: Upregulation
of heme oxygenase. American Journal of Physiology-Heart and Circulatory
Physiology 2005 289:H92-H98.
- George, R.L., McGwin, G. Jr, Schwacha, M.G., Metzger, J., Cross,
J.M., Chaudry, I.H., Rue, L.W. III. (2005) The association between
gender and mortality among burn patients as modified by age. Journal of
Burn Care and Rehabilitation 26:416-421.
- Alexander, M., Daniel, T., Chaudry, I.H., Schwacha, M.G. (2005)
Opiate analgesics contribute to the development of post-injury
immunosuppression. Journal of Surgical Research 129:161-168.
- Calvano S.E., Xiao W., Richards D.R., Felciano R.M., Baker H.V., Cho
R.J., Chen R.O., Brownstein B.H., Cobb J.P., Tschoeke S.K.,
Miller-Graziano C., Moldawer L.L., Mindrinos M.N., Davis R.W., Tompkins
R.G., Lowry S.F.; Inflammation and Host Response to Injury Large Scale
Collab. Res. Program (including Schwacha M.). (2005) A network-based
analysis of systemic inflammation in humans. Nature 437: 1032-1037.
- Hubbard, W.J., Choudhry, M., Schwacha, M.G., Kerby, J.D., Rue, L.W.,
3rd, Bland, K.I., Chaudry, I.H. (2005) Cecal ligation and puncture.
Shock 24(suppl 1):52-57.
- Choudhry, M.A., Schwacha, M.G., Hubbard, W.J., Kerby, J.D., Rue,
L.W., Bland, K.I., Chaudry, I.H. (2005) Gender differences in acute
response to trauma-hemorrhage. Shock 24(suppl 1):101-106.
- Dienstknecht, T., Schwacha, M.G., Kang, S-C, Rue, L.W., III, Bland,
K.I., Chaudry, I.H. (2004) Sex steroid-mediated regulation of
macrophage/monocyte function in a two-hit model of trauma-hemorrhage and
sepsis. Cytokine 25: 110-118.
- Yokoyama Y, Kitchens W.C., Toth B., Schwacha M.G., Rue L.W., Bland
K.I., Chaudry I.H. (2004) The role of IL-10 in regulating
proinflammatory cytokine release by Kupffer cells following
trauma-hemorrhage. American Journal of Physiology-Gastrointestinal and
Liver Physiology 286: G942-G946.
- Kang, S-C, Matsutani, T., Choudhry, M.A., Schwacha, M.G., Rue, L.W.,
Bland, K.I., Chaudry, I.H. (2004) Are the immune responses different in
middle aged and young mice following bone fracture, tissue trauma and
hemorrhage? Cytokine 26: 223-230.
- Schneider C.P., Schwacha, M.G., Chaudry, I.H. (2004) The role of
interleukin-10 in the regulation of the systemic inflammatory response
following trauma-hemorrhage. Biochimica et Biophysica Acta-Molecular
Basis of Disease 1689: 22-32.
- Alexander, M., Daniel, T., Chaudry, I.H., Schwacha, M.G. (2004) MAP
kinases differentially regulate the expression of macrophage
hyperactivity after thermal injury. Journal of Cellular Physiology
201:35-44.
- Yokoyama, Y., Toth, B., Kitchens, W.C., Schwacha, M.G., Rue L.W.,
III, Bland, K.I., Chaudry, I.H. (2004) Estradiol's effect on portal
response to endothelin-1 after trauma-hemorrhage. Journal of Surgical
Research 121:25-30.
- Toth, B. Alexander, M., Daniel, T., Chaudry, I.H., Hubbard, W.J.,
Schwacha, M.G. (2004) The role of γδ T-cells in the regulation of
neutrophil-mediated tissue damage after thermal injury. Journal of
Leukocyte Biology 76:542-552.
- Kang, S-C, Choudhry, M.A., Matsutani, T. Schwacha, M.G., Rue, L.W.,
III, Bland, K.I., Chaudry, I.H. (2004) Splenectomy differentially
influences immune responses in various tissue compartments of the body.
Cytokine 28:101-108.
- Toth, B., Yokoyama, Y., Schwacha, M.G., George, R.L., Rue, L.W. III,
Bland, K.I., Chaudry, I.H. (2004) Insights into the role of IL-6 in the
induction of hepatic injury following trauma-hemorrhagic shock. Journal
of Applied Physiology 97: 2184-2189.
- Schwacha, M.G. Macrophages and post-burn immune dysfunction. (2003)
Burns 29:1-14.
- Toth, B., Schwacha, M.G., Kuebler, J.F., Bland, K.I., Wang, P.,
Chaudry, I.H. (2003) Gender dimorphism in neutrophil priming and
activation following trauma-hemorrhagic shock. International Journal of
Molecular Medicine 11: 357-364.
- Yokoyama Y., Schwacha, M.G., Bland, K.I., Chaudry, I.H. (2003)
Effect of estradiol administration on splanchnic perfusion following
trauma-hemorrhage and sepsis. Current Opinion in Critical Care
9:137-142.
- Yokoyama, Y., Schwacha, M.G., Bland, K.I., Chaudry, I.H. (2003) The
role of female sex hormones in preventing mortality in sepsis. Advances
in Sepsis 2:127-132.
- Yokoyama, Y., Kuebler, J.F., Matsutani, T., Schwacha, M.G., Bland,
K.I., Chaudry, I.H. (2003) Mechanism of the salutary effects of
17β-estradiol following trauma-hemorrhage: Direct downregulation of
Kupffer cell proinflammatory cytokine production Cytokine 21: 91-97.
- Chaudry, I.H., Samy, T.S., Schwacha, M.G., Wang, P., Rue, L., Bland,
K.I. (2003) Endocrine targets in experimental shock. Journal of Trauma
54: S118-125.
- Knöferl, M.W. Angele, M.K., Schwacha, M.G., Samy, T.S.A.,
Bland, K.I., Chaudry, I.H. (2003) Immunoprotection in proestrus females
following trauma-hemorrhage: the pivotal role of estrogen receptors.
Cellular Immunology 222: 27-34.
- Schneider C.P., Schwacha, M.G., Samy, T.S.A., Bland, K.I., Chaudry,
I.H. (2003) Androgen-mediated modulation of macrophage function after
trauma-hemorrhage: the central role of 5?-dihydrotestosterone. Journal
of Applied Physiology 95: 104-112.
- Schwacha, M.G., Chaudry, I.H., Alexander, M. (2003) Regulation of
macrophage IL-10 production post-injury via β2 integrin signaling and
the p38 MAP kinase pathway. Shock 20: 529-535.
- Yokoyama, Y., Kitchens, W.C., Toth, B., Schwacha, M.G., Bland, K.I.,
Chaudry, I.H. (2003) Upregulation of hepatic prolactin receptor gene
expression by 17β-estradiol following trauma-hemorrhage. Journal of
Applied Physiology 95: 2530-2536.
- Yokoyama, Y., Toth, B., Kitchens, W.C., Schwacha, M.G., Bland, K.I.,
Chaudry, I.H. (2003) Role of thromboxane in producing portal
hypertension following trauma-hemorrhage. American Journal of
Physiology-Gastrointestinal and Liver Physiology 285: G1293-G1299.
- Toth, B., Yokoyama, Y., Kuebler, J.F., Schwacha, M.G., Rue, L.W.,
III, Bland, K.I., Chaudry, I.H. (2003) Gender differences in hepatic
heme oxygenase expression and activity following trauma-hemorrhagic
shock. Archives of Surgery 138: 1375-1382.
- Schwacha, M.G., Chung, C-S, Ayala, A., Bland, K.I., Chaudry, I.H.
(2002) Cyclooxygenase 2-mediated suppression of macrophage
interleukin-12 production following thermal injury. American Journal of
Physiology-Cell Physiology 282:C263-C270.
- Knöferl, M.W., Angele, M.K., Schwacha, M.G., Bland, K.I.,
Chaudry, I.H. (2002) Preservation of splenic immune functions following
trauma-hemorrhage by female sex hormones. Critical Care Medicine
30:888-893.
- Knöferl, M.W., Schwacha, M.G., Jarrar, D., Angele, M.K.,
Fragoza, K., Bland, K.I., Chaudry, I.H. (2002) Estrogen pretreatment
protects males against hypoxia-induced immune depression. American
Journal of Physiology-Cell Physiology 282:C1087-C1092.
- Knöferl, M.W., Angele, M.K., Diodato, M.D. Schwacha, M.G.,
Ayala, A., Cioffi, W.G., Bland, K.I., Chaudry, I.H. (2002) Female sex
hormones regulate macrophage function following trauma-hemorrhage and
prevent increased mortality from subsequent sepsis. Annals of Surgery
235:105-112.
- Schwacha, M.G., Schneider, C.P., Chaudry, I.H. (2002) Differential
expression and tissue compartmentalization of the inflammatory response
following thermal injury. Cytokine 17:266-274.
- Nickel, E.A., Schwacha, M.G., Schneider, C.P., Bland, K.I., Chaudry,
I.H. (2002) Trauma-Haemorrhage-induced alterations in thymic prolactin
receptor expression: Implications in immune dysfunction. Cytokine 18:
127-132.
- Yokoyama, Y., Schwacha, M.G., Samy, T.S.A., Bland, K.I., Chaudry,
I.H. (2002) Gender dimorphism in immune responses following trauma and
hemorrhage. Immunologic Research 26:63-76.
- Schwacha, M.G., Chaudry, I.H. (2002) The cellular basis of post-burn
immunosuppression: macrophages and mediators. International Journal of
Molecular Medicine 10: 239-243.
- Alexander, M., Chaudry, I.H., Schwacha, M.G. (2002) Relationships
between burn size, immunosuppression, and macrophage hyperactivity in a
murine model of thermal injury. Cellular Immunology 220: 63-69.
- Diodato, M.D., Knöferl, M.W., Schwacha, M.G., Bland, K.I.,
Chaudry, I.H. (2001) Gender differences in the inflammatory response and
survival following haemorrhage and subsequent sepsis. Cytokine
14:162-169.
- Samy, T.S.A., Knöferl, M.W., Zeng, R., Schwacha, M.G., Bland,
K.I., Chaudry, I.H. (2001) Divergent immune responses in male and female
mice after trauma-hemorrhage: Dimorphic alterations in T lymphocyte
steroidogenic enzyme activities. Endocrinology 142:3519-3529.
- Knöferl, M.W., Jarrar, D., Angele, M.K., Ayala, A.. Schwacha,
M.G., Bland, K.I., Chaudry, I.H. (2001) Immunoprotective role of
17β-estradiol: Normalization of immune responses in ovariectomized
females following trauma-hemorrhage. American Journal of Physiology-Cell
Physiology 281: C1131-1138.
- Schwacha, M.G., Schneider, C.P., Bland, K.I., Chaudry, I.H. (2001)
Resistance of macrophages to the suppressive effect of interleukin-10
following thermal injury. American Journal of Physiology-Cell Physiology
281: C1180-1187.
- Knöferl, M.W., Schwacha, M.G., Bland, K.I., Chaudry, I.H.
(2001) Mechanism of immunoprotection in proestrus females following
trauma-hemorrhage: The pivotal role of estrogen receptors. Surgical
Forum 52: 148-149.
- Schneider, C.P., Schwacha, M.G., Bland, K.I., Chaudry, I.H. (2001)
Do peripheral T-cells reflect the alterations in tissue fixed
lymphocytes following trauma-hemorrhage: influence of gender. Surgical
Forum 52: 151-154.
- Knöferl, M.W., Diodato, M.D., Schwacha, M.G., Cioffi, W.G.,
Bland, K.I., Chaudry, I.H. (2001) Cyclooxygenase-2 mediated regulation
of Kupffer cell IL-6 production following trauma-hemorrhage and
subsequent sepsis. Shock 16: 479-483.
- Kahlke, V., Angele, M.K., Ayala, A., Schwacha, M.G., Cioffi, W.G.,
Bland, K.I., Chaudry, I.H. (2000) Immune dysfunction following
trauma-haemorrhage: influence of gender and age. Cytokine 12: 69-77.
- Angele, M.K., Knöferl, M.W., Schwacha, M.G., Cioffi, W.G.,
Bland, K.I., Ayala, A., Chaudry, I.H. (2000) Impairment of wound healing
following hemorrhage is associated with decreased collagen deposition.
Critical Care and Shock 3: 49-56.
- Kahlke, V., Angele, M.K., Schwacha, M.G., Ayala, A., Cioffi, W.G.,
Bland, K.I., Chaudry, I.H. (2000) Reversal of sexual dimorphism in
splenic T-lymphocyte responses following trauma-hemorrhage with aging.
American Journal of Physiology 278: C509-C516.
- Schwacha, M.G., Ayala, A., Chaudry, I.H. (2000) Insights into the
role of ÷ø T-lymphocytes in the immunopathogenic response to thermal
injury. Journal of Leukocyte Biology 67:644-650.
- Angele, M.K., Schwacha, M.G., Ayala, A., Chaudry, I.H. (2000) Effect
of gender and sex hormones on immune responses following shock. Shock
14:81-90.
- Angele, M.K., Fitzal, F., Small, N., Knöferl, M.W., Schwacha,
M.G., Ayala, A., Wang, P., Chaudry, I.H. (2000) L-arginine attenuates
trauma-hemorrhage induced liver injury. Critical Care Medicine
28:3242-3248.
- Schneider, C.P., Nickel, E.A., Samy, T.S.A., Schwacha, M.G., Bland,
K.I., Chaudry, I.H. (2000) The aromatase inhibitor
4-hydroxyandrostenedione restores immune responses following
trauma-hemorrhage in males and decreases mortality from subsequent
sepsis. Shock 14:347-353.
- Samy, T.S.A., Schwacha, M.G., Cioffi, W.G., Bland, K.I., Chaudry,
I.H. (2000) Androgen and estrogen receptors in splenic T lymphocytes:
effects of flutamide and trauma-hemorrhage. Shock 14:465-470.
- Schwacha, M.G., Knöferl, M.W., Chaudry, I.H. (2000) Does burn
wound excision after thermal injury attenuate subsequent macrophage
hyperactivity and immunosuppression? Shock 14:623-628.
- Knöferl, M.W., Jarrar, D., Schwacha, M.G., Angele, M.K.,
Cioffi, W.G., Bland, K.I., Chaudry, I.H. (2000) Severe hypoxemia in the
absence of blood loss causes a gender dimorphic immune response.
American Journal of Physiology 279:C2004-C2010.
- Samy, T.S.A., Schwacha, M.G., Chung, C-S, Cioffi, W.G., Bland, K.I.,
Chaudry, I.H. (1999) Proteasome participates in the alteration of signal
transduction in T and B lymphocytes following trauma-hemorrhage.
Biochimica et Biophysica Acta 1453: 92-104.
- Schwacha, M.G., Somers, S.D. (1999) Thermal injury induced
enhancement of oxidative metabolism by mononuclear phagocytes. Journal
of Burn Care and Rehabilitation 20: 37-41.
- McFarlane, A.S., Schwacha, M.G., Meissler, J.J.,Jr., Eisenstein,
T.K. (1999) In vivo blockage of nitric oxide inhibits immunosuppression
induced by attenuated Salmonella, potentates Salmonella infection and
inhibits macrophage/PMN influx into the spleen. Infection and Immunity
67:891-898.
- Angele, M.K., Schwacha, M.G., Smail, N., Catania, R.A., Ayala, A.,
Cioffi, W.G., Chaudry, I.H. (1999) Hypoxemia in the absence of blood
loss upregulates inducible nitric oxide synthase expression and activity
in macrophages. American Journal of Physiology 276: C285-C290.
- Catania, R.A., Schwacha, M.G., Cioffi, W.G., Bland, K.I., Chaudry,
I.H. (1999) Does uninjured skin release pro-inflammatory cytokines
following trauma and hemorrhage? Archives of Surgery 134: 368-374.
- Song, G.Y., Chung, C-S., Schwacha, M.G., Jarrar, D., Chaudry, I.H.,
Ayala, A. (1999) Splenic immune suppression in sepsis: a role for
IL-10-induced changes in P38 MAPK signaling. Journal of Surgical
Research 83:36-43.
- Angele, M.K., Knöferl, M.W., Schwacha, M.G., Ayala, A., Bland,
K.I., Cioffi, W.G., Josephson, S.L., Chaudry, I.H. (1999) Hemorrhage
decreases macrophage inflammatory protein-2 and IL-6 release: A possible
mechanism for increased wound infection. Annals of Surgery 229:
651-661.
- Angele M.A., Knöferl, M.W., Song, G.Y., Schwacha, M.G., Ayala,
A., Cioffi, W.G., Bland, K.I., Chaudry, I.H. (1999) Gender dimorphism of
the immune response following trauma-hemorrhage: involvement of p38 MAP
kinase signal transduction pathways. Surgical Forum 50: 278-280.
- Schwacha, M.G., Knöferl, M.W., Samy, T.S.A., Ayala, A.,
Chaudry, I.H. (1999) The immunologic consequences of hemorrhagic shock.
Critical Care and Shock 2:42-64.
- Angele, M.K., Xu, Y-X, Ayala, A., Schwacha, M.G., Catania, R.A.,
Cioffi, W.G., Bland, K.I. Chaudry, I.H. (1999) Gender dimorphism in
trauma-hemorrhage induced thymocyte apoptosis. Shock 12: 316-322.
- Angele M.A., Knöferl, M.W., Schwacha, M.G., Ayala, A., Cioffi,
W.G., Bland, K.I., Chaudry, I.H. (1999) Sex steroids regulate pro- and
anti-inflammatory cytokine release by macrophages after
trauma-hemorrhage. American Journal of Physiology 277: C35-C42.
- Schwacha, M.G., Ayala, A., Cioffi, W.G., Bland, K.I., Chaudry I.H.
(1999) Role of protein kinase C in cyclic AMP-mediated suppression of
T-lymphocyte activation following burn injury. Biochimica et Biophysica
Acta 1455: 45-53.
- Schwacha, M.G., Somers, S.D. (1998) Thermal injury induced
immunosuppression in mice: The role of macrophage derived reactive
nitrogen intermediates. Journal of Leukocyte Biology 63: 51-58.
- Schwacha, M.G., Somers, S.D. (1998) Thermal injury induces
macrophage hyperactivity through pertussis toxin-sensitive and
-insensitive pathways. Shock 9: 249-255.
- Schwacha, M.G., Samy, T.S.A., Cantania, R.A., Chaudry, I.H. (1998) Thermal injury alters macrophage responses to prostaglandin E2: Contribution to the enhancement of inducible nitric oxide synthase activity. Journal of Leukocyte Biology 64: 740-746.
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