Smith, W.Z., Harrison, H.B., Salhanick, M.A., Higgins, R.A., Oritz, A., Olson, J.D., Schwacha, M.G., Harrison, C.R., Aydelotte, J.D., Stewart, R.M., Dent, D.L. (2013) A small amount can make a difference: a prospective human study of the paradoxical coagulation characteristics of hemothorax. American Journal of Surgery 206:904-909.
Rani M, Zhang Q, Schwacha MG. (2014) Burn wound gamma-delta T-cells support a Th-2 and Th- 17 immune response. Journal of Burn Care and Research 35:46-53. (Lonza Award recipient)
Schwacha, M.G., Rani, M., Zhang, Q., Nunez-Cantu, O., Cap, A.P. (2014) Mitochondrial damage- associated molecular patterns (DAMPs) activate gamma delta (γδ) T-cells. Innate Immunity. 20:261-268.
Rani, M., Zhang, Q., Scherer, M.A., Cap, A.P., Schwacha, M.G. (2014) Activated skin γδ T-cells regulate T-cell infiltration of the wound site after burn. Innate Immunity (epub ahead of print).
Basic, translational and clinical research: Research constitutes a significant component of our department, with innovative projects leading to greater scientific understanding and improved human health. The Department of Surgery at UTHSCSA has the expertise, resources, facilities, and environment to conduct research in both the basic and the clinical sciences. The research is multidisciplinary and includes investigators with specialties in surgery, medicine, physiology, pathology, immunology, microbiology, and molecular biology. Through the interaction of these diverse areas of expertise, is it possible to accomplish the goals of obtaining new and pertinent information for better care and management of surgical patients. This combined team effort and integrative approach contributes to improved procedures for diagnosis, treatment, and critical care that will result in decreased complications, morbidities, and mortality rates in our patient population.
Although the research interests in the department are multifaceted, particular areas of interest include the immunopathology of trauma, angiogenesis and tissue regeneration, vascular metallomics and cancer epidemiology. Our research endeavors are funded by the NIH, Department of Defense, the VA and other sources.
The Department of Surgery at UTHSCSA has a strong commitment to the training of residents and fellows in research. Investigators have trained and are training several residents/fellows who have received various awards and presented at high profile conferences and meetings nationally and internationally.