Paula K. Shireman, MD, Vascular/Endovascular Surgical Research Laboratory
Dr. Shireman obtained her medical degree from Indiana University School of Medicine in Indianapolis, IN in 1990 and completed her Vascular Surgery training at Loyola University Medical Center in Maywood, IL in 1998. She is currently certified with the American Board of Surgery in both General Surgery and Vascular Surgery. Dr. Shireman joined the Vascular Surgery Division at the Health Science Center in 1999. After arriving at the Health Science Center, Dr. Shireman completed her masters program in Clinical Investigation and received numerous grants for research from the NIH, the Department of Veteran Affairs, Howard Hughes Medical Institute, the American Heart Association, and the University of Texas Health Science Center at San Antonio. In 2004 Dr. Shireman was appointed to the faculty for the Barshop Institute for Longevity and Aging Studies. She currently is serving as the Vice Dean for Research for the School of Medicine where she is a tenured Professor in the Department of Surgery. Dr. Shireman performs open and endovascular procedures as well as trains residents and medical students. Her published research is primarily in macrophage biology, angiogenesis, stem cells, tissue regeneration and microRNAs. In her role role as Vice Dean, she is responsible for 5 research centers/institutes, facilitating a telemedicine initiative, integrating research and educational activities along the South Texas Border in conjunction with the Regional Academic Health Center in Edinburg and Harlingen, as well as promoting research activities for the School of Medicine.
Dr. Shireman's lab studies the inflammatory-mediated mechanisms of angiogenesis and skeletal muscle regeneration. We are particularly interested in how hematopoietic stem cells, myogenic stem cells and inflammatory cells interact to form muscle after injury. A better understanding of muscle regeneration will be useful in tissue regeneration strategies for limb salvage.