Paula K. Shireman, MD, MS, Vascular/Endovascular Surgical Research Laboratory
Paula K. Shireman, MD, MS is an academic vascular surgeon and physician scientist in the School of Medicine at the University of Texas Health Science Center at San Antonio and the South Texas Veterans Health Care System where she is a tenured Professor in the Departments of Surgery and Microbiology & Immunology, holds the Dielmann Chair in Surgery and serves as the Scientific Advisor for Clinical Trials Xpress. She obtained her MD from Indiana University and MS in Clinical investigation at the University of Texas Health Science Center, San Antonio. Her research interests are in muscle regeneration, imaging modalities to study extremity injuries and outcomes of vascular trauma. Her health services research studies the long term outcomes of extremity vascular trauma in Active Service and Veterans of Operation Iraqi Freedom/Operation Enduring Freedom/Operation New Dawn as well as care transitions and health care system improvement. She is the Co-Principal Investigator of the Institutional Clinical Translational Science Award (CTSA) responsible for strategic partnership with our CTSA affiliated institutions, biostatistics, study design and biomedical informatics cores, and evaluation of all CTSA programs. She incorporated Lean Six Sigma methods into research administration to streamline processes and increase efficiency. Dr. Shireman has been active in the development of a centralized clinical trials office for the University of Texas System, Clinical Trials Xpress, which utilizes a centralized IRB, master clinical trial agreements and single, centrally-negotiated clinical trial budget and shared Medicare coverage analysis to improve efficiency and decrease the regulatory burden of clinical trials. She has extensive experience in team building, research and administration. Dr. Shireman has presented on two panels for the Institute of Medicine regarding sharing clinical trial data. Dr. Shireman’s research is primarily funded by the National Institutes of Health, Veterans Administration and Department of Defense.
Dr. Shireman's lab studies the inflammatory-mediated mechanisms of angiogenesis and skeletal muscle regeneration. We are particularly interested in how hematopoietic stem cells, myogenic stem cells and inflammatory cells interact to form muscle after injury. A better understanding of muscle regeneration will be useful in tissue regeneration strategies for limb salvage.